There are, I suppose, two minor, mini-jokes in this comic, neither of which is good. One is the point of his talk, the emoticon-in-parentheses-problem, which is not that funny an issue to talk about, and anyway you're not the first to think of it, sorry. (Thanks, forums!) The other one is the line about being kicked out of furry conventions, which rather than make me laugh made me just wonder, yet again, why the furry obsession, Randall?
Other thoughts: We know you got to talk to the google people once, please stop imagining yourself as even more important. Also, do TED talks count as an internet meme? You never hear about them anywhere else, do you? Alt-text: Wow, a your-mom joke and a three year old pluto joke. You win the shit prize, alt-text.
Update: I am profoundly disappointed that in 195 forum posts, only one person had the decency to point out that we've seen all this before. To the rest of you, who spent 194 posts debating the emoticon-parenthesis question: you are only deceiving yourselves!
Later Update: Come to think of it, does today's comic remind anyone of anything? Say, a recent guest comic over at Pictures for Sad Children?
waaaay later update: Kurt points out this SMBC from 2005. You just try and tell me this idea isn't old.